Scientists at
Michigan State University (MSU) have found exposure to the hormone progesterone activates genes that trigger inflammation in the mammary gland and may be a key factor in increasing the risk of breast cancer.
Progesterone is a naturally occurring steroid hormone and promotes development of the normal mammary gland.
Progesterone previously has been identified as a risk factor for breast cancer, and in a study published in the “Journal of Steroid Biochemistry and Molecular Biology,” MSU scientists examined the genes activated by progesterone and the effects of their activation in a mouse model system.
"Progesterone turns on a wide array of genes involved in several biological processes, including cell adhesion, cell survival and inflammation," says physiology professor Sandra Haslam, co-author of the paper and director of the Breast Cancer and the Environment Research Center at MSU. "All of these processes may be relevant to the development of breast cancer."
The study shows progesterone significantly regulates 162 genes in pubertal cells, 104 genes in adult cells and 68 genes at both developmental stages. A number of these genes make small proteins, called chemokines, which control the process of inflammation.
Inflammation is a process where white blood cells move into a tissue. One type of white blood cell which moves to the breast during inflammation is a macrophage. Macrophages normally enter growing glands and help them develop, building blood vessels and reshaping growing tissue.
"Macrophages also may promote the development of tumors, such as breast cancer, as they make blood vessels,” Haslam says.
Source: MSU
Gretchen Cochran, Innovation & Jobs editor, may be reached
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